Publications

Antonio-Herrera L, Bergthaler A. Molecular Basis for muscle loss that causes cachexia. Nature 2023 May;617/7962):684-685. doi: 10.1038/d41586-023-01527-7. PMID: 37165218. News & Views

Amman, F., Markt, R., Endler, L. et al. Viral variant-resolved wastewater surveillance of SARS-CoV-2 at national scale. Nature Biotechnology 2022 Jul 18. doi: 10.1038/s41587-022-01387-y. PMID: 35851376.

Baazim H, Antonio-Herrera L, Bergthaler A. The interplay of immunology and cachexia in infection and cancer. Nature Reviews Immunology 2021 Oct 4:1–13. doi: 10.1038/s41577-021-00624-w. Epub ahead of print. PMID: 34608281; PMCID:PMC8489366. Review

Agerer B, Koblischke M, Gudipati V, Montaño-Gutierrez LF, Smyth M, Popa A, Genger JW, Endler L, Florian DM, Mühlgrabner V, Graninger M, Aberle SW, Husa AM, Shaw LE, Lercher A, Gattinger P, Torralba-Gombau R, Trapin D, Penz T, Barreca D, Fae I, Wenda S, Traugott M, Walder G, Pickl WF, Thiel V, Allerberger F, Stockinger H, Puchhammer-Stöckl E, Weninger W, Fischer G, Hoepler W, Pawelka E, Zoufaly A, Valenta R, Bock C, Paster W, Geyeregger R, Farlik M, Halbritter F, Huppa JB, Aberle JH, Bergthaler A. SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses. Science Immunology 2021 Mar 4;6(57):eabg6461. doi: 10.1126/sciimmunol.abg6461. PMID: 33664060; PMCID: PMC8224398

Popa A, Genger JW, Nicholson MD, Penz T, Schmid D, Aberle SW, Agerer B, Lercher A, Endler L, Colaço H, Smyth M, Schuster M, Grau ML, Martínez-Jiménez F, Pich O, Borena W, Pawelka E, Keszei Z, Senekowitsch M, Laine J, Aberle JH, Redlberger-Fritz M, Karolyi M, Zoufaly A, Maritschnik S, Borkovec M, Hufnagl P, Nairz M, Weiss G, Wolfinger MT, von Laer D, Superti-Furga G, Lopez-Bigas N, Puchhammer-Stöckl E, Allerberger F, Michor F, Bock C, Bergthaler A. Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2. Science Translational Medicine 2020 Dec 9; 12(573):eabe2555. doi: 10.1126/scitranslmed.abe2555. Epub 2020 Nov 23. PMID: 33229462; PMCID: PMC7857414

Lercher A, Popa AM, Viczenczova C, Kosack LJ, Klavins K, Agerer B, Opitz CA, Lanz TV, Platten M, Bergthaler A. Type I interferon reprograms hepatocyte metabolism and reveals novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis. PLoS Pathogens 2020 Oct 12;16(10):e1008973. PMID: 33045014

Lercher A, Baazim H, Bergthaler A. Systemic Immunometabolism: Challenges and Opportunities. Immunity 2020 Sep 15;53(3):496-509. doi: 10.1016/j.immuni. 2020.08.012. PMID: 32937151; PMCID: PMC7491485. Review

Krausgruber T, Fortelny N, Fife-Gernedl V, Senekowitsch M, Schuster LC, Lercher A, Nemc A, Schmidt C, Rendeiro F, Bergthaler A, Bock C. Structural cells are key regulators of organ-specific immune responses. Nature 2020 Jul;583(7815):296-302. PMID: 32612232

Lercher A, Bhattacharya A, Popa AM, Caldera M, Schlapansky MF, Baazim H, Agerer B, Gürtl B, Kosack L, Májek P, Brunner JS, Vitko D, Pinter T, Genger JW, Orlova A, Pikor N, Reil D, Ozsvár-Kozma M, Kalinke U, Ludewig B, Moriggl R, Bennett KL, Menche J, Cheng PN, Schabbauer G, Trauner T, Klavins K, Bergthaler A. Type I interferon signaling disrupts the hepatic urea cycle and alters systemic metabolism to suppress T cell function. Immunity 2019 Nov 26. PMID: 31784108

Baazim H, Schweiger M, Moschinger M, Xu H, Scherer T, Popa A, Gallage S, Ali A, Khamina K, Kosack L, Vilagos B, Smyth M, Lercher A, Friske J, Merkler D, Aderem A, Helbich TH, Heikenwälder M, Lang PA, Zechner R and Bergthaler A. CD8(+) T cells induce cachexia during chronic viral infection. Nature Immunology 2019 Jun;20(6):701-710. PMID: 31110314

Kosack L, Wingelhofer B, Popa A, Orlova A, Agerer B, Vilagos B, Majek P, Parapatics K, Lercher A, Ringler A, Klughammer J, Smyth M, Khamina K, Baazim H, de Araujo ED, Rosa DA, Park J, Tin G, Ahmar S, Gunning PT, Bock C, Siddle HV,Woods GM, Kubicek S, Murchison EP, Bennett KL, Moriggl R*, Bergthaler A*. ERBB-STAT3 axis drives Tasmanian devil facial tumor disease. Cancer Cell 2019 Jan 14;35(1):125-139.e9. PMID: 30645971

Bhattacharya A, Hegazy AN, Deigendesch N, Kosack L, Cupovic J, Kandasamy RK, Hildebrandt A, Merkler D, Kühl AA, Schliehe C, Panse I, Vilagos B, Khamina K, Arnold I, Flatz L, Xu HC, Lang PA, Aderem A, Superti-Furga G, Colinge J, Ludewig B, Löhning M*, Bergthaler A*. Superoxide dismutase 1 protects hepatocytes from type I interferon-driven oxidative damage. Immunity 2015 Nov 17;43(5):974-86. PMID: 26588782

Schliehe C, Flynn EK, Vilagos B, Richson U, Swaminathan S, Bosnjak B, Bauer L, Kandasamy RK, Griesshammer IM, Kosack L, Schmitz F, Litvak V, Sissons J, Lercher A, Bhattacharya A, Khamina K, Trivett AL, Tessarollo L, Mesteri I, Hladik A, Merkler D, Kubicek S, Knapp S, Epstein MM, Symer DE, Aderem A, Bergthaler A. The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection. Nature Immunology 2015 Jan;16(1):67-74. PMID: 25419628